Drug delivery to the inner ear
نویسندگان
چکیده
منابع مشابه
Principles of local drug delivery to the inner ear.
As more and more substances have been shown in preclinical studies to be capable of preventing damage to the inner ear from exposure to noise, ototoxic drugs, ischemia, infection, inflammation, mechanical trauma and other insults, it is becoming very important to develop feasible and safe methods for the targeted delivery of drugs to specific regions in the inner ear. Recently developed methods...
متن کاملPharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by Round Window Application
Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empiricallybased. As a result, consequences of changes in delivery method, applied drug concentration or even small alterations in treatment protocols have been difficult to predict. Since direct measurements of drug ...
متن کاملBovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear
Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles coul...
متن کاملNovel In Vivo Imaging Analysis of an Inner Ear Drug Delivery System in Mice: Comparison of Inner Ear Drug Concentrations over Time after Transtympanic and Systemic Injections
OBJECTIVE Systemic steroid injections are used to treat idiopathic sudden-onset sensorineural hearing loss (ISSHL) and some inner ear disorders. Recent studies show that transtympanic (TT) steroid injections are effective for treating ISSHL. As in vivo monitoring of drug delivery dynamics for inner ear is lacking, its time course and dispersion of drugs is unknown. Here, we used a new in vivo i...
متن کاملUnderstanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
Background The round window membrane (RWM) functions as the primary biological barrier for therapeutic agents in the inner ear via local application. Previous studies on inner ear nano-drug delivery systems mostly focused on their pharmacokinetics and distribution in the inner ear, but seldom on the interaction with the RWM. Clarifying the transport mechanism of nanoparticulate carriers across ...
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ژورنال
عنوان ژورنال: Journal of Neural Engineering
سال: 2012
ISSN: 1741-2560,1741-2552
DOI: 10.1088/1741-2560/9/6/065002